HGH and Insulin

HGH and insulin are biological antagonists, this means that the elevation of one will lead to the decrease of the other. Nonetheless both insulin and HGH save the same purpose, they are both responsible for growth of the organism. They are also both products of recombinant DNA technology. While insulin pulls nutrients into the cell, growth hormone stimulates muscular, skeletal and neurological growth.

What is the Human Growth Hormone?

HGH is one of the hormones of the anterior pituitary gland, its main function is cellular growth in the human body. Biochemically, the structure of HGH consists of a 191 amino acids polypeptide chain with a 45% helical and 8 alpha helices. The hormone is found in both men and women at slightly the same amounts, men have slight more HGH than women.

HGH is considered anabolic because it also triggers anabolic reactions like the repair, growth and creation of new body tissues. It is very useful in wound healing, burn victims and fractured bones.  HGH helps to repair microtears in muscle thus resulting in more growth.

The pituitary gland is responsible for the production and secretion of HGH. Throughout the day and mostly during the night, Growth Hormone is synthesized, stored and secreted by the anterior portion of the pituitary gland. To naturally stimulate the hypothalamus to produce more HGH, get enough sleep, intense exercise and avoid sugary foods. Elevated blood sugar levels, cortisol, glucose and even HGH decrease the production and secretion of HGH. Growth Hormone secretion reaches its highest peak during sleeping but the above factors greatly alter the cycle if not monitored.

On the other hand, elevated blood levels of cortisol, glucose and even growth hormone itself decrease production and secretion.  While GH is released into your bloodstream at fairly regular intervals (between 3-5 hours) the amount released is heavily dependent upon the factors I mentioned earlier in this paragraph.  It’s safe to say, however, that for most of us, the majority of growth hormone secretion occurs during sleep.

What is Insulin?

Insulin is naturally produced by the beta cells of the pancreas in the human body. The pancreas is found tucked away behind the stomach. Insulin is primarily responsible for nutrient translocation. In simple terms, Insulin can be explained as the “key” required to un-lock cells allowing sugar to enter in the cell and meet the energy requirements of the cell. Also this is important for regulation of blood sugar levels, mostly by reducing the high levels of sugar in the blood stream which can damage cells.

The discovery of insulin in 1921 by Frederick Banting and Charles Best was a major stride in the medical community. Some has referred it as the “most powerful” hormone in the body. Blood sugar levels in non diabetic patience, are very tightly and carefully controlled by Insulin, maintaining them within a safe and healthy range. Insulin is essential for life in both animals and humans, it regulates a lot of metabolic reactions in the body.

Insulin mechanism of action

In a healthy, non-diabetic patient, when you take food, the blood sugar levels tend to rise. The rise in blood sugar levels stimulates the beta cells of the pancreas to release of insulin. Insulin then acts on the cells of the muscles, fat cells and liver cells in the body to absorb glucose(sugar) from the blood. Consequently this reduces the blood sugar levels back to normal. Insulin can also be considered as a storage hormone since it facilitates storage of glucose into the body when the body has excess. It is also insulin responsible for signalling the liver to stop releasing glucose into the bloodstream.

HGH mechanism of action

The Human Growth Hormone is a natural secretion of the pituitary gland. After secretion by the pituitary gland it enters the blood stream. From the blood, HGH acts upon a number of different cells in the body but mainly it goes to the liver. In the liver HGH stimulates the release of Growth factors like insulin like Growth Factor(IGF-1).

HGH binds to two receptors outside a cell known as Human Growth Hormone Binding Proteins(hGHpb). As result the Human Growth Hormone joins the two receptors together, in turn causing a shift in the receptor protein and triggering a cascade of reactions. It is these cascade of reactions that influence cell growth and regeneration, multiplication as well as directing the function of other enzymes and hormones, and the overall brain function.

Why isn’t there an insulin or HGH Pill?

If you are wondering why scientists haven`t made HGH or Insulin pills, you aren`t the only one. We all know how uncomfortable injections can be, especially in kids.

A pill would be easy to administer to the kid, Its easy to swallow. That being the case, still there hasn`t been a successful oral form available. Its not hat they haven`t tried it at all. Actually scientists have been working on this for over 80 years. The major drawback is that insulin and HGH are hormones. Hormones are proteins. As well know, the digestive system is good at digesting proteins and insulin and HGH are no exception. The Human Growth Hormone and insulin are delicate proteins, even excessively shaking the injections can ruin them. They probably won`t make it through the digestive system to perform their function in the bloodstream.

Besides, the absorption process would be quiet difficult due to the intestinal lining. Nonetheless there is still hope, a lot of big pharmaceutical companies are still trying to find a way. It might tarry but surely one day we`ll receive some good news.

How HGH is made?

Thanks to recombinant DNA technology, HGH can now be made in a laboratory and made easily accessible to us. Back in the 1950s, the only source of HGH was Human cadavers. Recombinant DNA technology allows scientists to make bio-identical replicas of hormones naturally produced in the body like insulin and HGH. It was introduced in 1985 by Genetech as a major breakthrough to help children with Growth Hormone deficiency. Before the discovery of recombinant DNA, HGH was extracted raw from the pituitary gland of Human cadavers.

How Insulin is made?

Naturally insulin is produced by beta cells in the pancreas known as the islets of Langerhans. Insulin is a very crucial hormone in the body and its absence in diabetics can lead to serious health complications. Thanks to the discovery of recombinant DNA which made insulin affordable and easily accessible to diabetic patients. Recombinant DNA refers to the process when a human gene is inserted into the genetic material of a common bacterium. This “recombinant” micro-organism would now have the ability to  reproduce the protein encoded by the human gene.

Final Verdict: Growth Hormone and Insulin are friends!

The cooperative effect of recombinant Human Growth Hormone and exogenous insulin in reference to the whole body as well as skeletal muscle protein metabolism has not been investigated recently. The following study investigated the effect of insulin and recombinant HGH during euglycemic clamping and concurrent amino acid supplementation.

The study involved 23 normal volunteers. The subjects in the postabsorptive state were either treated with recombinant HGH for three days continuously before going through a metabolic check up. The GH group had 10 individuals and the non treated(CTRL) group had 13 individuals. The dosage was 0.2 mg/kg/day (n = 5) or 0.1 mg/kg/day (n = 5). After that, all the subjects were then given an infusion of tritated phenylalanine and 14C-labeled leucine, followed by measuring of baseline protein kinetics in the CTRL and GH groups.

The subjects were then administered a euglycemic insulin infusion (1 mU/kg/min) along with concurrent amino acid infusion. Kinetic and protein measurements were repeated at steady state.

The results were amazing. Insulin and HGH separately indeed stimulated an increase in skeletal muscle and protein muscle balance. However the combination of the two resulted in an even higher net protein balance. Conclusively, insulin and recombinant DNA in the presence of glucose and amino acids combine to improve both body metabolism and skeletal muscle kinetics.

Benefits of insulin

  1. Enhancement of weight loss
  2. Say goodbye to being ‘hungry’ and  sugar
  3. Reduced risk of diseases
  4. General psychological wellness and cognition.
  5. Clearer and healthy skin

Benefits of HGH:

  • Stimulates cell reproduction
  • Raises fatty acids concentration levels
  • Improved cardiovascular health
  • Increases glucose density
  • Highly stimulates growth and development
  • facilitates weight loss
  • Well defined bone structure and strong bones
  • Enhanced wound and fracture healing
  • Release of IGF-1