HGH and Insulin

HGH and insulin are biological antagonists, this means that the elevation of one will lead to the decrease of the other. Nonetheless both insulin and HGH save the same purpose, they are both responsible for the growth of the organism. They are also both products of recombinant DNA technology. While insulin pulls nutrients into the cell, growth hormone stimulates muscular, skeletal and neurological growth.

What is the Human Growth Hormone?

HGH is one of the hormones of the anterior pituitary gland, its main function is cellular growth in the human body. The Human Growth Hormone is a protein and it comprises of 191 amino acids. Synthetic HGH found in HGH injection is a bio-equivalent to the body`s naturally produced HGH. It also contains 191 amino acids and it has the same mechanism of action and efficacy as natural HGH.

The Human Growth Hormone comes with amazing anabolic properties like enhanced cell growth and regeneration, cell repair and muscle growth. This is why HGH is often prescribed to burn victims and orthopedic patients.

The pituitary gland is responsible for the production and secretion of HGH. Throughout the day and mostly during the night, Growth Hormone is synthesized, stored and secreted by the anterior portion of the pituitary gland. To naturally stimulate the hypothalamus to produce more HGH, get enough sleep, intense exercise and avoid sugary foods. Elevated blood sugar levels, cortisol, glucose, and even HGH decrease the production and secretion of HGH. Growth Hormone secretion reaches its highest peak during sleeping but the above factors greatly alter the cycle if not monitored.

On the other hand, elevated blood levels of cortisol, glucose and even growth hormone itself decrease production and secretion.  While GH is released into your bloodstream at fairly regular intervals (between 3-5 hours) the amount released is heavily dependent upon the factors I mentioned earlier in this paragraph.  It’s safe to say, however, that for most of us, the majority of growth hormone secretion occurs during sleep.

What is Insulin?

Insulin is naturally produced by the beta cells of the pancreas in the human body. The pancreas is found tucked away behind the stomach. Insulin is primarily responsible for nutrient translocation. In simple terms, Insulin can be explained as the “key” required to unlock cells allowing sugar to enter in the cell and meet the energy requirements of the cell. Also, this is important for the regulation of blood sugar levels, mostly by reducing the high levels of sugar in the bloodstream which can damage cells.

The discovery of insulin in 1921 by Frederick Banting and Charles Best was a major stride in the medical community. Some has referred it as the “most powerful” hormone in the body. Blood sugar levels in non-diabetic patients, are very tightly and carefully controlled by Insulin, maintaining them within a safe and healthy range. Insulin is essential for life in both animals and humans, it regulates a lot of metabolic reactions in the body.

Insulin mechanism of Action

In a healthy, non-diabetic patient, when you take food, the blood sugar levels tend to rise. The rise in blood sugar levels stimulates the beta cells of the pancreas to release of insulin. Insulin then acts on the cells of the muscles, fat cells and liver cells in the body to absorb glucose(sugar) from the blood. Consequently, this reduces the blood sugar levels back to normal. Insulin can also be considered as a storage hormone since it facilitates storage of glucose into the body when the body has excess. It is also insulin responsible for signaling the liver to stop releasing glucose into the bloodstream.

HGH mechanism of action?

The mechanism of action of synthetic HGH injections is identical to the mechanism of action of natural pituitary produced HGH. When you take an HGH injection, it enters the bloodstream and is transported to the liver. When it reaches the liver, HGH stimulates the liver to produce Growth factors, usually IGF-1. It usually binds to two receptors outside a cell. HGH joins the two receptors together (Human Growth Hormone Binding Proteins(hGHpb)). The joining together of these two hGHpb causes a shift within the receptor protein and triggers a cascade of reactions. It is through these series of reaction that cell growth, multiplication, and cell regeneration is achieved.

Why isn`t there an insulin or HGH Pill?

If you are wondering why scientists haven`t made HGH or Insulin pills, you aren`t the only one. We all know how uncomfortable injections can be, especially in kids.

A pill would be easy to administer to the kid, it’s easy to swallow. That being the case still, there hasn`t been a successful oral form available. It is not that they haven`t tried it at all. Actually, scientists have been working on this for over 80 years. The major drawback is that insulin and HGH are hormones. Hormones are proteins. As well know, the digestive system is good at digesting proteins and insulin and HGH are no exception.

The Human Growth Hormone and insulin are delicate proteins, even excessively shaking the injections can ruin the protein structure. They probably won`t make it through the digestive system to perform their function in the bloodstream. Another barrier is the absorption of HGH protein structure through the intestinal wall which seems impossible. A lot of researchers sponsored by large pharmaceutical companies are still working on this so there is still some hope that in the near future people can take HGH orally.

How HGH is made?

The Human Growth Hormone is manufactured using recombinant DNA technology. Recombinant DNA technology allows creating bio-identical hormones naturally produced in the human body like insulin and HGH. Initially proposed in 1985 by Genetech, it was a big step forward fighting children HGH deficiency. Before recombinant DNA method was invented, HGH was extracted from human bodies.

How Insulin is made?

Naturally, insulin is produced by beta cells in the pancreas known as the islets of Langerhans. Insulin is a very crucial hormone in the body and its absence in diabetics can lead to serious health complications. Thanks to the discovery of recombinant DNA which made insulin affordable and easily accessible to diabetic patients. Recombinant DNA refers to the process when a human gene is inserted into the genetic material of a common bacterium. This “recombinant” micro-organism would now have the ability to reproduce the protein encoded by the human gene.

Final Verdict: Growth Hormone and Insulin are friends!

The cooperative effect of recombinant Human Growth Hormone and exogenous insulin in reference to the whole body as well as skeletal muscle protein metabolism has not been investigated recently. The following study investigated the effect of insulin and recombinant HGH during euglycemic clamping and concurrent amino acid supplementation.

The study involved 23 normal volunteers. The subjects in the postabsorptive state were either treated with recombinant HGH for three days continuously before going through a metabolic checkup. The GH group had 10 individuals and the non-treated(CTRL) group had 13 individuals. The dosage was 0.2 mg/kg/day (n = 5) or 0.1 mg/kg/day (n = 5). After that, all the subjects were then given an infusion of tritiated phenylalanine and 14C-labeled leucine, followed by measuring of baseline protein kinetics in the CTRL and GH groups.

The subjects were then administered a euglycemic insulin infusion (1 mU/kg/min) along with concurrent amino acid infusion. Kinetic and protein measurements were repeated at steady state.

The results were amazing. Insulin and HGH separately indeed stimulated an increase in skeletal muscle and protein muscle balance. However, the combination of the two resulted in an even higher net protein balance. Conclusively, insulin and recombinant DNA in the presence of glucose and amino acids combine to improve both body metabolism and skeletal muscle kinetics.

Benefits of insulin

  1. Enhancement of weight loss
  2. Say goodbye to being ‘hungry’ and sugar crashes.
  3. Reduced risk of diseases
  4. General psychological wellness and cognition.
  5. Clearer and healthy skin

Benefits of HGH

  • Reinvigorates the body`s functions and boosts the immune system.
  • Facilitates weight loss and at the same time adds lean muscle.
  • Better wound and fracture healing.
  • Slows down aging and makes you feel and look younger.
  • Reinvigorates the natural skin glow as well as hair
  • It is the best treatment available for Growth Hormone Deficiency and dwarfism.